OFF-X Safety Assistant
OFF-X gives AI assistants direct access to curated clinical safety, pharmacovigilance and preclinical toxicology intelligence: adverse events and safety alerts for drugs, targets, mechanisms, drug classes and modalities, with OFF-X evidence scores and the underlying source references. Answers are grounded in OFF-X content and cite the source records.
How to access
Every option requires a Clarivate account with an active OFF-X subscription. Choose the guide for the AI assistant or integration you use:
| Integration | Availability | Guide |
|---|---|---|
| Claude claude.ai, Claude Desktop and the Claude mobile apps | Available | Claude setup guide |
| Microsoft 365 Copilot Chat the ready-made connector in Copilot Chat | Not currently supported | — |
| Microsoft Copilot Studio your own Copilot Studio agents | Available | Microsoft Copilot Studio setup guide |
| API (server-to-server) your own applications and automated workflows, with an API key | Available | API (server-to-server) setup guide |
Example questions
Once connected, try asking your AI assistant:
- “What are the main safety liabilities of PD-1 inhibitors, and which adverse events are considered on-target?”
- “Compare the cardiovascular safety profiles of semaglutide and tirzepatide.”
- “Which KRAS G12C inhibitors have reported dose-limiting toxicities, and what were they?”
- “Have any CAR-T therapies been placed on clinical hold or discontinued for safety reasons?”
- “What preclinical toxicology findings have been reported for JAK1 inhibitors?”
Available tools
- OFF-X Safety Assistant: Use this tool when the user asks for OFF-X clinical safety, pharmacovigilance, or preclinical toxicology intelligence about a drug, drug combination, molecular target, mechanism of action (target-action), drug class, or modality (product category).
Support
For help with access or setup, please contact [email protected].
Legal
Your use of OFF-X through any of these integrations is subject to Clarivate's terms.