OFF-X Safety Assistant

Server-to-server (API) access

Use this option to call OFF-X Safety Assistant from your own applications, agents or automated workflows, without an interactive sign-in. Requests authenticate with a Clarivate API key and speak the Model Context Protocol (MCP), so any MCP client library that can send a custom header can connect.

Prerequisites

A OFF-X subscription that includes API access. Contact your Clarivate account manager to have it enabled for your organisation.
An API key from the Clarivate Developer Portal: sign in, open the OFF-X Safety Assistant API-key API, and subscribe an application to it. The key is issued to that application.

Connection details

Endpoint	`https://api.clarivate.com/lifesciences/mcp-offx/apikey/mcp`
Protocol	Model Context Protocol (JSON-RPC 2.0)
Transport	Streamable HTTP
Authentication	API key in the `X-ApiKey` request header

Example: list the available tools

curl -X POST 'https://api.clarivate.com/lifesciences/mcp-offx/apikey/mcp' \
  -H 'X-ApiKey: <your API key>' \
  -H 'Content-Type: application/json' \
  -H 'Accept: application/json, text/event-stream' \
  -d '{"jsonrpc": "2.0", "id": 1, "method": "tools/list"}'

Call a tool the same way with "method": "tools/call" and "params": {"name": "<tool name>", "arguments": {...}}.

Good practice

Keep the API key on your servers. Never embed it in a browser, mobile or desktop application.
Content returned is governed by your organisation's OFF-X subscription and the Terms of Use below.

Available tools

OFF-X Safety Assistant: Use this tool when the user asks for OFF-X clinical safety, pharmacovigilance, or preclinical toxicology intelligence about a drug, drug combination, molecular target, mechanism of action (target-action), drug class, or modality (product category).

Support

For help with access or setup, please contact [email protected].

Legal

Your use of OFF-X through any of these integrations is subject to Clarivate's terms.

Looking for an AI assistant integration instead? See all access options.