OFF-X Safety Assistant

Connecting from Claude

This guide explains how to connect OFF-X Safety Assistant to Claude so that Claude can answer your questions with OFF-X content. A connector added once is available on claude.ai, in Claude Desktop and in the Claude mobile apps.

Prerequisites

• A Clarivate account with an active OFF-X subscription. Without one, sign-in succeeds but the tools return an error saying that a valid subscription is required.
• A Claude plan that supports connectors: Pro, Max, Team or Enterprise.
• On a Team or Enterprise plan, the connector must first be enabled for your organisation by a Claude Owner (Step 1). Pro and Max users can go straight to Step 2.

Step 1: Enable the connector for your organisation (Team and Enterprise only)

This is a one-off step for a Claude organisation Owner or Primary Owner. Members cannot add a connector their organisation has not enabled.

1. In Claude, open Admin settings and select Connectors.
2. Browse the connector directory, find OFF-X Safety Assistant and add it for your organisation.
3. If OFF-X Safety Assistant is not listed in the directory, select Add custom connector instead and enter:

   Name	OFF-X Safety Assistant
   Remote MCP server URL	https://api.clarivate.com/lifesciences/mcp-offx/mcp
   OAuth Client ID / Secret	Leave blank: Claude registers itself automatically.

Enabling the connector does not share any OFF-X data or credentials: each member still connects with their own Clarivate account in Step 2, and only sees content their own subscription covers.

Step 2: Connect your Clarivate account

Each user does this once.

1. Sign in to claude.ai (or open Claude Desktop).
2. Go to Customize → Connectors → Discover. In some versions of Claude this is under Settings → Connectors → Browse connectors.
3. Search for OFF-X Safety Assistant, select it and click Connect. On a Team or Enterprise plan, a connector your organisation has added may already be listed under Connectors, ready to connect.
4. You are redirected to Clarivate. Sign in with the account that holds your OFF-X subscription and approve the consent screen.
5. Back in Claude, the connector shows as Connected.

Step 3: Use it in a conversation

1. Start a new chat, open the + (tools) menu below the message box and check that OFF-X Safety Assistant is switched on.
2. Ask a question that needs OFF-X content. The first time Claude uses a tool it may ask for permission: choose Allow.
3. Claude cites the OFF-X content it used, so you can open the source record.

Example questions

Once connected, try asking your AI assistant:

• “What are the main safety liabilities of PD-1 inhibitors, and which adverse events are considered on-target?”
• “Compare the cardiovascular safety profiles of semaglutide and tirzepatide.”
• “Which KRAS G12C inhibitors have reported dose-limiting toxicities, and what were they?”
• “Have any CAR-T therapies been placed on clinical hold or discontinued for safety reasons?”
• “What preclinical toxicology findings have been reported for JAK1 inhibitors?”

Available tools

• OFF-X Safety Assistant: Use this tool when the user asks for OFF-X clinical safety, pharmacovigilance, or preclinical toxicology intelligence about a drug, drug combination, molecular target, mechanism of action (target-action), drug class, or modality (product category).

Troubleshooting

• The connector is not listed. On a Team or Enterprise plan, ask your Claude Owner to complete Step 1.
• Tools return an error about a required subscription. The account you signed in with has no active OFF-X subscription. Disconnect, then connect again with the right account.
• The connector shows as connected but requests fail, or Claude asks you to sign in again. Sign-ins expire after a period of time. Open the connector, select Disconnect, then Connect again.
• Claude answers without using the connector. Check that it is switched on in that chat (Step 3), and mention OFF-X in your question.

For support, please contact [email protected].

Legal

Your use of OFF-X through any of these integrations is subject to Clarivate's terms.

• Privacy Policy
• Terms of Use

Using a different assistant? See all access options.